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OC(=O)C1=CC2=C(C=C1)C1(OC2=O)C2=CC=C(O)C=C2OC2=CC(O)=CC=C12
5-fold and dramatically reduces the actin concentration at which ATPase is half-maximal (KATPase) 30-fold
Transl Oncol
Formula: C19H21NO2
Smiles: CC1(C)OC2=CC=C(NC3=NC(NC4=CC(OC)=C(OC)C(=C4)OC)=NC=C3F)N=C2NC1=O
Poziotinib l (chloride) OC(=O)C1=CC2=C(C=C1)C1(OC2=O)C2=CC=C(O)C=C2OC2=CC(O)=CC=C12Poziotinib , also known as HM781 36B and NOV120101, is an orally bioavailable, quinazoline based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781 36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a
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