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Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo
The production of 2HG is believed to contribute to the formation and progression of cancer
Smiles: CC1C=CC(=CC=1)C1=CSC(=N1)C1=CC(CCC)=NC=C1
CAS Number: 182431-12-5
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N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 Skin-targeted inhibition of PPAR β/δN106, CAS No. 862974 25 2, is a potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a. Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. The small ubiquitin like modifier type 1 (SUMO 1) is a regulator of SERCA2a and the gene transfer of SUMO 1 in rodents and large animal models of heart
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