R-112 Catalog No.:M6572-2 PubMed PMID: 15196000

Name: R-112 Catalog No.:M6572-2 PubMed PMID: 15196000
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PubMed PMID: 15196000

R-112 Catalog No.:M6572-2 PubMed PMID: 15196000R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti IgE cross linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol L) or basophils (histamine release, EC(50) = 280 nmol L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization

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