CAL-130 - CAS# 1431697-74-3 Catalog No.:M9912-10 increase microvascular permeability

increase microvascular permeability

InChi: InChI=1S/C20H24N2O2

Smiles: CN1CCN(CC1)S(=O)(=O)C1=CC(C2NC3=C(C(=O)N=2)N(C)N=C3CCC)=C(C=C1)OCC

and rosemary

Formula: C19H23NO2

CAL-130 - CAS# 1431697-74-3 Catalog No.:M9912-10 increase microvascular permeabilityCAL 130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3 kinase (PI3K) Akt activation is common in T cell acute lymphoblastic leukemia (T ALL). Although four distinct class I PI3K isoforms (, , , ) could participate in T ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3K or PI3K alone can support