SB-408124 Catalog No.:M7777-10 InChi: InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10

InChi: InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10

(2014) Neurosci Lett

2009 Apr 3

N'-bis(4-fluorophenyl)-

weekly or twice a week TAS4464 administration led to prominent antitumor activity in multiple human tumor xenograft mouse models including both hematologic and solid tumors without marked weight loss

SB-408124 Catalog No.:M7777-10 InChi: InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10SB 408124 is a elective non peptide orexin OX1 receptor antagonist (Kb values are 21. 7 and 1405 nM for human OX1 and OX2 receptors respectively). A critical role for the orexin 1 receptor (OX1R) in complex emotional behavior is emerging, such as overactivation of the OX1R pathway being associated with panic or anxiety states. Product information CAS Number: 288150 92 5 Molecular Weight: 356. 37 Formula: C19H18F2N4O Synonym: SB408124 free base SB