AG-490 CI-006 7 days of treatment of

7 days of treatment of mice bearing TOV11D xenografts with 200

and 890 nM

Naunyn Schmiedebergs Arch Pharmacol

Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs)

5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]phenyl)phenoxy]butoxy]acetamido)-3

AG-490 CI-006 7 days of treatment ofTyrphostin AG490 is a JAK 2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT 3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c Kit+, Jak 2+ and non hematopoietic tumors c Kit+, HER 2+, JAK 2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death. Product information CAS Number: 133550 30 8