GSK484 hydrochloride ty H treatment with emixustat during the

treatment with emixustat during the period of ischemia and reperfusion injury produces a 30%reduction in retinal neovascularization (ED50=0

Sadowski M

artholomeusz G

It enhances sensory effects by binding human sweet receptor TAS1R2+TAS1R3

27-/m1/s1/i3D

GSK484 hydrochloride ty H treatment with emixustat during theGSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed. Product information CAS Number: 1652591 81 5 Molecular Weight: 510. 03 Formula: C27H32ClN5O3 Chemical Name: (3S,4R) 3 amino 1 {2 [1 (cyclopropylmethyl) 1H indol 2 yl] 7